Levetiracetam
Verfasst: Do 11. Jan 2018, 14:18
Es gibt eine (Internet) Info wonach in einigen Fällen CK mit dem Präparat Levetiracetam erfolgreich behandelt worden sein soll.
Es ist allerdings nur eine Internetveröffentlichung, die wohl auch mehr eine Werbung sein soll. Ein Artikel in der Literatur steht offenbar noch aus.
Hier die Info:
Levetiracetam IV: new cluster headache treatment
Authors: J. Krusz, J. Cagle; Anodyne Headache and PainCare, Dallas, TX
Levetiracetam is used for control of seizures and has been useful for refractory headaches and pain, both orally and intravenously (1-3).We describe treatment of an acute flareup of cluster headache with intravenous levetiracetam. Five case reports are described at this point. All were males with onset of cluster headaches. 1 patient had co-existent migraines. At the headache clinic, an IV was placed and levetiracetam was given IV. 400-800mg test dose was given. 800mg was given every 10 minutes with monitoring. Patients rated their cluster severity on a 0-10 NRS scale. Average severity was 8/10. All 5 cases reported cessation of their cluster headache attacks with treatment. All were placed on oral levetiracetam for cluster prophylaxis. The average dose was about 7520mg over about 45-60 minutes. No side effects of any kind were reported other than transient drowsiness in 2 patients. IV levetiracetam is a possible option for treating acute cluster headaches. It is not available and has to be extracted. Safety, tolerability and, most importantly, efficacy have been demonstrated in this and other open-label studies (3) treating migraine and cluster headaches. Double-blind studies are warranted for levetiracetam IV.
Es ist allerdings nur eine Internetveröffentlichung, die wohl auch mehr eine Werbung sein soll. Ein Artikel in der Literatur steht offenbar noch aus.
Hier die Info:
Levetiracetam IV: new cluster headache treatment
Authors: J. Krusz, J. Cagle; Anodyne Headache and PainCare, Dallas, TX
Levetiracetam is used for control of seizures and has been useful for refractory headaches and pain, both orally and intravenously (1-3).We describe treatment of an acute flareup of cluster headache with intravenous levetiracetam. Five case reports are described at this point. All were males with onset of cluster headaches. 1 patient had co-existent migraines. At the headache clinic, an IV was placed and levetiracetam was given IV. 400-800mg test dose was given. 800mg was given every 10 minutes with monitoring. Patients rated their cluster severity on a 0-10 NRS scale. Average severity was 8/10. All 5 cases reported cessation of their cluster headache attacks with treatment. All were placed on oral levetiracetam for cluster prophylaxis. The average dose was about 7520mg over about 45-60 minutes. No side effects of any kind were reported other than transient drowsiness in 2 patients. IV levetiracetam is a possible option for treating acute cluster headaches. It is not available and has to be extracted. Safety, tolerability and, most importantly, efficacy have been demonstrated in this and other open-label studies (3) treating migraine and cluster headaches. Double-blind studies are warranted for levetiracetam IV.