Lipolysis und Cluster wer kann es übersetzen und erklären

[Archiv]

Wer kann es übersetzen?
So wie ich es verstehen, haben Clusterköpfe einen reduzierten Fettstoffwechsel während des Schlafs, weil ein Hormon des Hypothalamus diesen Stoffwechselvorgang regelt. Das schein ja der maßgebliche Zitronensäurezyklus zu sein, der gegenüber den Kohlenhydraten die vierfache Energiemenge frei setzt.
Ich selber bin weder in Biologie noch Englisch up to Day halt mehr als ein viertel Jahrhundert her, seitdem mir ein Lehrer dafür eine Note verpasst hat.


Diminished nocturnal lipolysis in cluster headache
A sign of central sympathetic dysregulation?
Eva Laudon Meyer, MD, Elisabet Waldenlind, MD PhD and Claude Marcus, MD PhD
From the Department of Neurology (Drs. Meyer and Waldenlind) and Department of Clinical Science Pediatric Endocrine Research Laboratory (Dr. Marcus), Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Address correspondence and reprint requests to Dr. E. Laudon Meyer, Department of Neurology, Karolinska Institutet R54, Huddinge University Hospital, S-141 86 Huddinge, Sweden; e-mail: eva.laudon-meyer@hs.se
Background: It is unclear whether the autonomic symptoms during cluster headache (CH) attacks are of central or peripheral origin. A metabolic change such as altered lipolysis would reflect a central autonomic dysfunction.
Objective: To study nocturnal lipolysis in CH patients and healthy control subjects.
Methods: Microdialysis technique was used to measure glycerol levels, the end-product of lipolysis, in subcutaneous adipose tissue. Ten CH patients participated, of whom six were studied in remission as well as during symptomatic periods but between headache attacks. Fifteen healthy control subjects were studied. Mean glycerol, glucose, and lactate concentrations were calculated for three 2-hour intervals between 2400 and 0600 hours.
Results: Compared with healthy control subjects, symptomatic CH patients had lower glycerol levels during all three intervals (69, 61, and 73% of control levels; p < 0.05). CH patients in remission showed lower glycerol levels from 0200 to 0600 hours (68 and 63% of control levels; p < 0.05). There were no significant differences between the CH groups. Compared with healthy control subjects, patients in remission also showed a significantly different nocturnal temporal pattern, demonstrating declining glycerol levels during the first part of the night.
Conclusions: Altered lipolysis was found in patients with CH, both in symptomatic periods and in remission. The altered lipolysis may be due to a reduced nocturnal sympathetic activity and consequently an indication of central sympathetic dysregulation and hypothalamic dysfunction.
________________________________________
Received November 4, 2002. Accepted in final form July 29, 2003.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table ofContents for the November 11 issue to find the title link for this article.

[Archiv]

Wer kann es übersetzen?
So wie ich es verstehen, haben Clusterköpfe einen reduzierten Fettstoffwechsel während des Schlafs, weil ein Hormon des Hypothalamus diesen Stoffwechselvorgang regelt. Das schein ja der maßgebliche Zitronensäurezyklus zu sein, der gegenüber den Kohlenhydraten die vierfache Energiemenge frei setzt.
Ich selber bin weder in Biologie noch Englisch up to Day halt mehr als ein viertel Jahrhundert her, seitdem mir ein Lehrer dafür eine Note verpasst hat.


Diminished nocturnal lipolysis in cluster headache
A sign of central sympathetic dysregulation?
Eva Laudon Meyer, MD, Elisabet Waldenlind, MD PhD and Claude Marcus, MD PhD
From the Department of Neurology (Drs. Meyer and Waldenlind) and Department of Clinical Science Pediatric Endocrine Research Laboratory (Dr. Marcus), Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Address correspondence and reprint requests to Dr. E. Laudon Meyer, Department of Neurology, Karolinska Institutet R54, Huddinge University Hospital, S-141 86 Huddinge, Sweden; e-mail: eva.laudon-meyer@hs.se
Background: It is unclear whether the autonomic symptoms during cluster headache (CH) attacks are of central or peripheral origin. A metabolic change such as altered lipolysis would reflect a central autonomic dysfunction.
Objective: To study nocturnal lipolysis in CH patients and healthy control subjects.
Methods: Microdialysis technique was used to measure glycerol levels, the end-product of lipolysis, in subcutaneous adipose tissue. Ten CH patients participated, of whom six were studied in remission as well as during symptomatic periods but between headache attacks. Fifteen healthy control subjects were studied. Mean glycerol, glucose, and lactate concentrations were calculated for three 2-hour intervals between 2400 and 0600 hours.
Results: Compared with healthy control subjects, symptomatic CH patients had lower glycerol levels during all three intervals (69, 61, and 73% of control levels; p < 0.05). CH patients in remission showed lower glycerol levels from 0200 to 0600 hours (68 and 63% of control levels; p < 0.05). There were no significant differences between the CH groups. Compared with healthy control subjects, patients in remission also showed a significantly different nocturnal temporal pattern, demonstrating declining glycerol levels during the first part of the night.
Conclusions: Altered lipolysis was found in patients with CH, both in symptomatic periods and in remission. The altered lipolysis may be due to a reduced nocturnal sympathetic activity and consequently an indication of central sympathetic dysregulation and hypothalamic dysfunction.
________________________________________
Received November 4, 2002. Accepted in final form July 29, 2003.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table ofContents for the November 11 issue to find the title link for this article.

Hallo Christian,

vielen Dank für Deine Mühe. Ich denke, dass die meisten von uns Laien sind, und froh sind, dass uns jemand wie Du auch einige Zusammenhänge erklären kann.
Mit den Jahren werden wir wohl noch einiges medizische und biologische lernen.

Ich hoffe, dass Du uns in Zukunft wieterhin hilfst und ich werde wohl beim Lesen neuer Information weiterhin wenig bekannte Stelle ins Forum stellen.

MFG

Dieter aus Aachen